After a car crash on the way to his wedding, the Chief of Surgery, Charlie Harris, of Toronto's Hope Zion Hospital ends up in a coma. He finds out that he can roam the hospital in spirit form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.